Trophic ulcers, treatment, causes of occurrence, symptoms, stages
Trophic ulcer (diabetic foot) is one of the most dangerous complications of the diabetes.
Due to constantly high blood sugar, diabetic patients have a disordered nervous conductivity in feet, which results in sensory loss, nonreactive for pressure, cold, various foot injuries. Any skin injury can lead to infection penetration and purulence (neuropathic foot). One more presentation of the neuropathic trophic ulcer is that leg skin loses its sensory to sweat and a dry skin often chaps but dry heels do not bother patients for lack of pain syndrome, which can result in ulceration.
Other kind of diabetic ulcers on feet is ischemic trophic ulcers emerging from disturbed circulation in foot vessels. Without sufficient nutrition, skin becomes too vulnerable for any injuries, which are hardly to be healed. Most commonly mixed form of diabetic foot infections takes place.
Foot problems, which can lead to trophic ulcers:
- corns and clavuses,
- ingrown nail,
- plantar wart,
- dry and cracked skin,
- skin fungus disease, especially between toes.
Treatment neglecting is highly prohibited as it can lead to serious consequences.
Diabetic foot stages
0 – no ulcers but high risk if any corns, fungi, etc,
1 - shallow ulcers,
2 - hollow ulcers without bone affection,
3 - hollow ulcers with bone affection,
4 – gangrene in toes,
5 – gangrene in feet.
The first and key condition in treatment of diabetes complications is a control of blood sugar. It is required to pay attention to minimal affections of lower limbs, which can turn into trophic ulcers without timely and adequate treatment. But for therapeutic effect a gangrene develops, which can be associated with lower limb amputation. In accordance with the statistics 25% of lower limb amputations are caused by impossibility to stop the process with therapeutic approach.
Treatment of trophic ulcers in feet with diabetes diagnosis, Cuba
Cuba offers treatment program of diabetic foot in two clinical units: Central Clilc Cira Garcia and La Pradera International rehabilitation center.
Treatment programs of trophic ulcers is rated for 14-21-28 days of a patient’s stay at clinic depending on a general condition of feet and overall state of the body.
HEBERPROT-P is a unique Cuban drug for treatment of trophic ulcers both ischemic and neuropathic. It also can be applied when treatment of trophic ulcer complications such as osteomyelitis and gangrene.
The main active constituent of the drug is a epidermal growth factor (EGF), 75 mg/fl, which has effect directly within injury spot.
Full product instruction on HEBERPROT-P can be found here.
HEBERPROT-P has been developing in the capital Center of gene engineering and vascular surgery (Неberbiotec) for about 20 years.
Currently it is widely used in Cuban specialized medical units but it does not go on sale.
Advantages of HEBERPROT-P when treatment of diabetic feet
- accelerates healing of strong lesions with a syndrome of ischemic and neuropathic diabetic feet; 3 weeks were enough for granulation of affected spots with dimensions of 1 up to 80 cm2
- reduces a number of sanitations and surgical interferences;
- reduces risk of infections and superinfections of lower limb ulcers of patients with gangrene, what reduces a number of surgeries a lot;
- greatly improves patients’ quality life with trophic ulcers due to the fact of decrease of surgical interferences and prevents from recurrences;
- cut expenses on hospitalizing as a cost of treatment with HEBERPROT-P is much more lower than that of endovascular surgeries and there are no complications typical for surgery.
Competent treatment with the current drug is able to prevent from lower limb amputation. According to the tests made effect from the treatment starts in 2 weeks after beginning of the treatment (injection course).
Results of treatment with HEBERPROT-P
In accordance with clinic tests ulcers of 50% of patients, who have completed a treatment course with this drug, were completely treated and 70% of patients managed to avoid amputations.